Rewiring immune evasion in liver metastases: WNT11 as a central node — a mini review

Liver metastasis (LM) poses a formidable barrier to effective immunotherapy, largely due to its uniquely immunosuppressive microenvironment and resistance to immune checkpoint blockade (ICB).Among emerging mechanisms, WNT11, a non-canonical WNT ligand, has been identified as a preclinical modulator...

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Detalhes bibliográficos

Principais autores:	Xiaoling Wang, Youcai Huang, Tingting Luo, Qinxian Liu, Yu Tian, Xiaoyu Hu, Yi Zheng, Shumin Fang, Yanyang Tu, Haining Zhen, Yu Guo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
coleção:	Frontiers in Oncology
Assuntos:	liver metastasis Wnt11 immune checkpoint blockade resistance CaMKII signaling tumor immune microenvironment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1666889/full
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