Rewiring immune evasion in liver metastases: WNT11 as a central node — a mini review

Liver metastasis (LM) poses a formidable barrier to effective immunotherapy, largely due to its uniquely immunosuppressive microenvironment and resistance to immune checkpoint blockade (ICB).Among emerging mechanisms, WNT11, a non-canonical WNT ligand, has been identified as a preclinical modulator...

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Hlavní autoři:	Xiaoling Wang, Youcai Huang, Tingting Luo, Qinxian Liu, Yu Tian, Xiaoyu Hu, Yi Zheng, Shumin Fang, Yanyang Tu, Haining Zhen, Yu Guo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-12-01
Edice:	Frontiers in Oncology
Témata:	liver metastasis Wnt11 immune checkpoint blockade resistance CaMKII signaling tumor immune microenvironment
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1666889/full
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