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Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and a CYP2D7 variant that mimics a CYP2D7/2D6 hyb...

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Principais autores: Andrea Gaedigk, Lazara K M Jaime, Joseph S Bertino, Jr, Anick Bérard, Victoria Pratt, L D Bradford, J S Leeder
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2010-10-01
Serier:Frontiers in Pharmacology
Fag:
CYP2D6
CYP2D6 poor metabolizer
CYP2D6*35B
CYP2D6*67
CYP2D6*79
CYP2D6*80
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00121/full
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