Engineering endoplasmic reticulum targeted metal–polyphenol curcumin nanomicelles for melanoma therapy

Abstract Melanoma has a high incidence and mortality, and current therapies are limited. Here, we developed TCPC, an ER-targeted nanomedicine guided by omics analysis. It consists of curcumin-loaded PEG–PCL nanomicelles coated with a Tannic acid–Cu metal–polyphenol network. Guided by clinical transc...

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Bibliografische Detailangaben

Hauptverfasser:	Yixun Zhang, Xuehua Wang, Hongli Zhang, Xin Zhou, Huichan He, Fen Zou, Yangjia Zhuo, Zhouda Cai, Qianfeng Xu, Wenjie Xie, Jundong Lin, Muqi Chen, Wenlian Zheng, Jianwei Chen, Jinsheng Liu, Huikang Yang, Weide Zhong, Ronghua Yang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-12-01
Schriftenreihe:	Journal of Nanobiotechnology
Schlagworte:	Endoplasmic reticulum stress Melanoma therapy Curcumin nanomicelle
Online-Zugang:	https://doi.org/10.1186/s12951-025-03941-7
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