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Engineering endoplasmic reticulum targeted metal–polyphenol curcumin nanomicelles for melanoma therapy

Abstract Melanoma has a high incidence and mortality, and current therapies are limited. Here, we developed TCPC, an ER-targeted nanomedicine guided by omics analysis. It consists of curcumin-loaded PEG–PCL nanomicelles coated with a Tannic acid–Cu metal–polyphenol network. Guided by clinical transc...

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Principais autores: Yixun Zhang, Xuehua Wang, Hongli Zhang, Xin Zhou, Huichan He, Fen Zou, Yangjia Zhuo, Zhouda Cai, Qianfeng Xu, Wenjie Xie, Jundong Lin, Muqi Chen, Wenlian Zheng, Jianwei Chen, Jinsheng Liu, Huikang Yang, Weide Zhong, Ronghua Yang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Journal of Nanobiotechnology
Fag:
Endoplasmic reticulum stress
Melanoma therapy
Curcumin nanomicelle
Online adgang:https://doi.org/10.1186/s12951-025-03941-7
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