Switching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma
Abstract CK2 is an antiapoptotic kinase overactive in various malignancies. Here we show that CK2 inhibition dramatically affects neuroblastoma growth both in vitro and in vivo. In particular, here we report on the identification of CK2-TN03, a CK2 inhibitor showing greater selectivity and cellular...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Nature Publishing Group
2026-01-01
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| سلاسل: | Experimental and Molecular Medicine |
| الوصول للمادة أونلاين: | https://doi.org/10.1038/s12276-025-01628-5 |
| الوسوم: |
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