Switching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma

Abstract CK2 is an antiapoptotic kinase overactive in various malignancies. Here we show that CK2 inhibition dramatically affects neuroblastoma growth both in vitro and in vivo. In particular, here we report on the identification of CK2-TN03, a CK2 inhibitor showing greater selectivity and cellular...

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Үндсэн зохиолчид:	Giulia Cazzanelli, Andrea Dalle Vedove, Francesca Broso, Matteo Burigotto, Jacopo Zasso, Giuseppe Aiello, Francesca Zonta, Andrea Astolfi, Maria Letizia Barreca, Maria Ruzzene, Luca Tiberi, Luca L. Fava, Alessandro Quattrone, Graziano Lolli
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Publishing Group 2026-01-01
Цуврал:	Experimental and Molecular Medicine
Онлайн хандалт:	https://doi.org/10.1038/s12276-025-01628-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!