Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading t...

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主要な著者:	Ben M. Flude, Giulio Nannetti, Paige Mitchell, Nina Compton, Chloe Richards, Meike Heurich, Andrea Brancale, Salvatore Ferla, Marcella Bassetto
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2021-02-01
シリーズ:	Viruses
主題:	MASP-2 coronaviruses molecular modelling drug repurposing
オンライン･アクセス:	https://www.mdpi.com/1999-4915/13/2/312
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