Conditional Fgfr1 Deletion in GnRH Neurons Leads to Minor Disruptions in the Reproductive Axis of Male and Female Mice

In humans and mice, inactivating mutations in fibroblast growth factor receptor 1 (Fgfr1) lead to gonadotropin-releasing hormone (GnRH) deficiency and a host of downstream reproductive disorders. It was unclear if Fgfr1 signaling directly upon GnRH neurons critically drove the establishment of a fun...

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Egile Nagusiak:	Cynthia Dela Cruz, Cassandra A. Horton, Kelsey N. Sanders, Nathan D. Andersen, Pei-San Tsai
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2021-02-01
Saila:	Frontiers in Endocrinology
Gaiak:	gonadotropin-releasing hormone neurons fibroblast growth factor receptor 1 conditional deletion hypothalamic-pituitary gonadal axis congenital hypogonadotropic hypogonadism Kallmann syndrome
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fendo.2020.588459/full
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