Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation

Abstract Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The identities of the other factors/events required to drive Pan...

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Detalhes bibliográficos

Principais autores:	Chun‐Mei Hu, Chien‐Chang Huang, Min‐Fen Hsu, Hung‐Jen Chien, Pei‐Jung Wu, Yi‐Ing Chen, Yung‐Ming Jeng, Shiue‐Cheng Tang, Mei‐Hsin Chung, Chia‐Ning Shen, Ming‐Chu Chang, Yu‐Ting Chang, Yu‐Wen Tien, Wen‐Hwa Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2023-12-01
coleção:	Advanced Science
Assuntos:	αSMA+ fibroblast activin A PanIN Kras Muc4
Acesso em linha:	https://doi.org/10.1002/advs.202301240
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