Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation

Abstract Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The identities of the other factors/events required to drive Pan...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Chun‐Mei Hu, Chien‐Chang Huang, Min‐Fen Hsu, Hung‐Jen Chien, Pei‐Jung Wu, Yi‐Ing Chen, Yung‐Ming Jeng, Shiue‐Cheng Tang, Mei‐Hsin Chung, Chia‐Ning Shen, Ming‐Chu Chang, Yu‐Ting Chang, Yu‐Wen Tien, Wen‐Hwa Lee
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2023-12-01
Цуврал:	Advanced Science
Нөхцлүүд:	αSMA+ fibroblast activin A PanIN Kras Muc4
Онлайн хандалт:	https://doi.org/10.1002/advs.202301240
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!