Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development

Abstract There is an important need to advance medication development for alcohol use disorder (AUD). BP1.3656B, a highly potent and selective histamine H3 receptor inverse agonist/antagonist, has been developed. Preclinical studies revealed high affinity, good pharmacokinetic profile, good brain pe...

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Detalhes bibliográficos

Principais autores:	Bernard Le Foll, Mickael Naassila, Jérôme Jeanblanc, Christian S. Hendershot, Jesus Chavarria, Thierry Calmels, Stéphane Krief, Isabelle Berrebi-Bertrand, Marilyne Uguen, David Perrin, Xavier Ligneau, Isabelle Boileau, Pablo M. Rusjan, Patricia Di Ciano, Pamela Sabioni, Marc Capet, Philippe Robert, Olivier Finance, Jeanne-Marie Lecomte, Jean Charles Schwartz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-01-01
Colecção:	Translational Psychiatry
Acesso em linha:	https://doi.org/10.1038/s41398-026-03807-y
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