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Sex-related differences in the efficacy of Baclofen enantiomers on self-administered alcohol in a binge drinking pattern and dopamine release in the core of the nucleus accumbens

Introduction: Clinical studies on the effectiveness of Baclofen in alcohol use disorder (AUD) yielded mixed results possibly because of differential effects of the enantiomers and sex-related differences. Here we examined the effect of the different Baclofen enantiomers on alcohol intake and on evok...

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Autors principals: Jérôme Jeanblanc, Pierre Sauton, Charles Houdant, Sandra Fernandez Rodriguez, Sofia Vilelas de Sousa, Virginie Jeanblanc, Sandra Bodeau, Laurence Labat, Marion Soichot, Florence Vorspan, Mickael Naassila
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-03-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2023.1146848/full
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