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Probing the activity of cysteine cathepsins in inflammatory bowel diseases

Abstract Cathepsin S is a cysteine protease that has been implicated in inflammatory bowel diseases (IBD) for its ability to promote visceral pain. Given its pro-inflammatory roles, we hypothesized that cathepsin S would drive other symptoms associated with IBD. Using activity-based probes, we inves...

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Autores principales: Bethany M. Anderson, Alexander R. Ziegler, Rhiannon I. Campden, Hongyi Wu, Bangyan Xu, Rachel M. McQuade, Simona E. Carbone, Daniel P. Poole, Alan E. Lomax, David E. Reed, Stephen J. Vanner, Robin M. Yates, Nigel W. Bunnett, Laura E. Edgington-Mitchell
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2025-12-01
Colección:Scientific Reports
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Acceso en línea:https://doi.org/10.1038/s41598-025-32489-7
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