Probing the activity of cysteine cathepsins in inflammatory bowel diseases

Abstract Cathepsin S is a cysteine protease that has been implicated in inflammatory bowel diseases (IBD) for its ability to promote visceral pain. Given its pro-inflammatory roles, we hypothesized that cathepsin S would drive other symptoms associated with IBD. Using activity-based probes, we inves...

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Bibliografski detalji

Glavni autori:	Bethany M. Anderson, Alexander R. Ziegler, Rhiannon I. Campden, Hongyi Wu, Bangyan Xu, Rachel M. McQuade, Simona E. Carbone, Daniel P. Poole, Alan E. Lomax, David E. Reed, Stephen J. Vanner, Robin M. Yates, Nigel W. Bunnett, Laura E. Edgington-Mitchell
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-12-01
Serija:	Scientific Reports
Teme:	Protease Cathepsin Activity-based probes Functional imaging Colitis Inflammatory bowel disease
Online pristup:	https://doi.org/10.1038/s41598-025-32489-7
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