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Innate cells and STAT1-dependent signals orchestrate vaccine-induced protection against invasive Cryptococcus infection

ABSTRACT Fungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. In previous studies, we determined that a heat-killed, Cryptococcus neoformans fbp1-deficient strain (HK-fbp1) is a potent vaccine candidate. We determined that vaccination with HK-fbp1 confers pr...

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Principais autores: Keyi Wang, Vanessa Espinosa, Yina Wang, Alexander Lemenze, Yosuke Kumamoto, Chaoyang Xue, Amariliz Rivera
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2024-10-01
coleção:mBio
Assuntos:
immunization
Cryptococcus neoformans
antifungal therapy
innate immunity
monocytes
neutrophils
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.01944-24
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