Innate cells and STAT1-dependent signals orchestrate vaccine-induced protection against invasive Cryptococcus infection

ABSTRACT Fungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. In previous studies, we determined that a heat-killed, Cryptococcus neoformans fbp1-deficient strain (HK-fbp1) is a potent vaccine candidate. We determined that vaccination with HK-fbp1 confers pr...

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Hlavní autoři:	Keyi Wang, Vanessa Espinosa, Yina Wang, Alexander Lemenze, Yosuke Kumamoto, Chaoyang Xue, Amariliz Rivera
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2024-10-01
Edice:	mBio
Témata:	immunization Cryptococcus neoformans antifungal therapy innate immunity monocytes neutrophils
On-line přístup:	https://journals.asm.org/doi/10.1128/mbio.01944-24
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