Pharmacokinetic Profiles of Pentoxifylline and Its 5-Hydroxyhexyl Metabolite Administered by Different Doses in Goats

This study examined dose-dependent alterations in the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl (M-I) metabolite in goats. Goats were administered PTX intravenously at doses of 10, 20, and 40 mg/kg. PTX and M-I plasma concentrations were quantified by HPLC. The t<sub>1/2ʎz</sub...

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Autors principals:	Orhan Corum, Tulay Avci, Mustafa Hitit, Pedro Marin, Mario Giorgi, Duygu Durna Corum, Devran Coskun, Serafettin Kartal, Hatice Rumeysa Ceyhan, Fatma Akin, Ibrahim Buyuktaskapulu, Kamil Uney
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-05-01
Col·lecció:	Animals
Matèries:	increasing dose goats 5-hydroxyhexyl metabolite pentoxifylline HPLC pharmacokinetics
Accés en línia:	https://www.mdpi.com/2076-2615/16/10/1524
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