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Pharmacokinetic Profiles of Pentoxifylline and Its 5-Hydroxyhexyl Metabolite Administered by Different Doses in Goats

This study examined dose-dependent alterations in the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl (M-I) metabolite in goats. Goats were administered PTX intravenously at doses of 10, 20, and 40 mg/kg. PTX and M-I plasma concentrations were quantified by HPLC. The t<sub>1/2ʎz</sub...

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Principais autores: Orhan Corum, Tulay Avci, Mustafa Hitit, Pedro Marin, Mario Giorgi, Duygu Durna Corum, Devran Coskun, Serafettin Kartal, Hatice Rumeysa Ceyhan, Fatma Akin, Ibrahim Buyuktaskapulu, Kamil Uney
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2026-05-01
Series:Animals
Assuntos:
increasing dose
goats
5-hydroxyhexyl metabolite
pentoxifylline
HPLC
pharmacokinetics
Acceso en liña:https://www.mdpi.com/2076-2615/16/10/1524
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