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Involvement of TMAO in exacerbating arsenic-induced neurotoxicity by activating the PERK/eIF2α/ATF4 pathway

Arsenic (As), a widely recognized environmental pollutant, has been implicated in the pathogenesis of various neuropsychiatric disorders, including anxiety and depression. Trimethylamine N-oxide (TMAO), a microbiota-host co-metabolite derived from dietary quaternary amines (e.g., choline), has been...

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Principais autores: Hong Zhang, Kai Ren, Xiaoting Ni, Liwang Lin, Longyu Li, Wenlei Zhang, Zengliang Gao, Shiao Ren, Lili Fan, Xin Hai
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-09-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
Trimethylamine N-oxide
Arsenic
Neurotoxicity
Depression
PERK/eIF2α/ATF4
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S014765132501036X
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