HLA dependency and possible clinical relevance of intrathecally synthesized anti-IgLON5 IgG4 in anti-IgLON5 disease

BackgroundAnti-IgLON5 disease is a rare chronic autoimmune disorder characterized by IgLON5 autoantibodies predominantly of the IgG4 subclass. Distinct pathogenic effects were described for anti-IgLON5 IgG1 and IgG4, however, with uncertain clinical relevance.MethodsIgLON5-specific IgG1-4 levels wer...

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Päätekijät:	Inga Koneczny, Stefan Macher, Markus Hutterer, Thomas Seifert-Held, Evelyn Berger-Sieczkowski, Morten Blaabjerg, Markus Breu, Jens Dreyhaupt, Livia Almeida Dutra, Marcus Erdler, Ingrid Fae, Gottfried Fischer, Florian Frommlet, Anna Heidbreder, Birgit Högl, Veronika Klose, Sigrid Klotz, Herburg Liendl, Mette S. Nissen, Jasmin Rahimi, Raphael Reinecke, Gerda Ricken, Ambra Stefani, Marie Süße, Helio A. G. Teive, Serge Weis, Thomas Berger, Lidia Sabater, Carles Gaig, Jan Lewerenz, Romana Höftberger
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2024-05-01
Sarja:	Frontiers in Immunology
Aiheet:	IgLON5 IgG4 HLA cerebrospinal fluid intrathecal synthesis therapy
Linkit:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376456/full
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