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Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans

Background: The agreement between plasma Aβ42/40 and Aβ positron emission tomography (PET) is approximately 75 %, with ∼85 % of discrepancies due to positive plasma but negative PET results. It is unclear whether this reflects Aβ changes in plasma before PET-detectable. Objectives: To assess the inf...

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Principais autores: Azadeh Feizpour, Vincent Doré, Pierrick Bourgeat, James D. Doecke, Rodrigo Canovas, Simon M. Laws, Tenielle Porter, Kun Huang, Christopher Fowler, Ralph N. Martins, Paul Maruff, Hamid R. Sohrabi, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Randall J. Bateman, Yan Li, Ovod Vitaliy, Larry Ward, Jurgen Mejan-Fripp, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-02-01
Colecção:The Journal of Prevention of Alzheimer's Disease
Assuntos:
Plasma Aβ42/40
Aβ-amyloid PET
Alzheimer’s disease
Progression risk
Primary prevention trial
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2274580725003966
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