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Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors

Numerous studies have shown the recovery of auditory function in mouse models of genetic hearing loss following AAV gene therapy, yet translation to the clinic has not yet been demonstrated. One limitation has been the lack of human inner ear cell lines or tissues for validating viral gene therapies...

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Bibliografiske detaljer
Principais autores: Edward S. A. van Beelen, Wouter H. van der Valk, Thijs O. Verhagen, John C. M. J. de Groot, Margot A. Madison, Wijs Shadmanfar, Erik F. Hensen, Jeroen C. Jansen, Peter Paul G. van Benthem, Jeffrey R. Holt, Heiko Locher
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-06-01
Serier:Biomolecules
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Online adgang:https://www.mdpi.com/2218-273X/12/6/816
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