Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations

Adeno-associated virus (AAV)-based brain gene therapies require precision without off-targeting of unaffected neurons to avoid side effects. The cerebellum and its cell populations, including granule and Purkinje cells, are vulnerable to neurodegeneration; hence, conditions to deliver the therapy to...

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Библиографические подробности

Главные авторы:	Magdalena Surdyka, Ewelina Jesion, Anna Niewiadomska-Cimicka, Yvon Trottier, Żaneta Kalinowska-Pośka, Maciej Figiel
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2022-09-01
Серии:	Frontiers in Molecular Neuroscience
Предметы:	adeno-associated virus (AAV) AAVrh10 AAV-PHP.eB cerebellum deep cerebellar nuclei Purkinje cells
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.947490/full
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