Pathophysiological Role and Medicinal Chemistry of A_2A Adenosine Receptor Antagonists in Alzheimer’s Disease

The A_2A adenosine receptor is a protein belonging to a family of four GPCR adenosine receptors. It is involved in the regulation of several pathophysiological conditions in both the central nervous system and periphery. In the brain, its localization at pre- and postsynaptic level in stri...

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Bibliographic Details

Main Authors:	Stefania Merighi, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Alessia Travagli, Manuela Nigro, Silvia Pasquini, R. Rama Suresh, Sung Won Kim, Nora D. Volkow, Kenneth A. Jacobson, Stefania Gessi
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2022-04-01
Series:	Molecules
Subjects:	A<sub>2A</sub> receptors A<sub>2A</sub> antagonist discovery Alzheimer’s disease memory loss neurodegeneration
Online Access:	https://www.mdpi.com/1420-3049/27/9/2680
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