Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

Summary: Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2). However, the physiological functions of Atx2 in neurons remain unknown. Here, using the powerful genetics...

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Autori principali:	Urko del Castillo, Rosalind Norkett, Wen Lu, Anna Serpinskaya, Vladimir I. Gelfand
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2022-01-01
Serie:	iScience
Soggetti:	Biological sciences Neuroscience Developmental neuroscience Cellular neuroscience Cell biology Developmental biology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589004221015078
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