53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes
Abstract 53BP1 accumulates at DNA double strand breaks (DSBs) and is implicated in non-homologous end joining (NHEJ), but the genetic interplay of 53BP1 with the NHEJ pathway (e.g., DNA-PKcs) is poorly understood. We examine blunt DSB NHEJ of Cas9 DSBs, which is dependent on core NHEJ factors, and f...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
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Nature Portfolio
2025-11-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-025-65329-3 |
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