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Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

Extracellular signal-regulated kinase (ERK) is a key effector of many growth signalling pathways. In this study, we visualise epidermal ERK activity in living mice using an ERK FRET biosensor. Under steady-state conditions, the epidermis occasionally revealed bursts of ERK activation patterns where...

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Principais autores: Toru Hiratsuka, Yoshihisa Fujita, Honda Naoki, Kazuhiro Aoki, Yuji Kamioka, Michiyuki Matsuda
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2015-02-01
Serier:eLife
Fag:
in vivo imaging
ERK
epidermis
cell cycle
Online adgang:https://elifesciences.org/articles/05178
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