Filamin-a increases the stability and plasma membrane expression of polycystin-2.
Polycystin-2 (PC2), encoded by the PKD2 gene, is mutated in ~15% of autosomal dominant polycystic kidney disease. Filamins are actin-binding proteins implicated in scaffolding and membrane stabilization. Here we studied the effects of filamin on PC2 stability using filamin-deficient human melanoma M...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science (PLoS)
2015-01-01
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| Reeks: | PLoS ONE |
| Online toegang: | https://doi.org/10.1371/journal.pone.0123018 |
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