Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt membranes of intracellular parasites to exert their function as part of the innate immune system of mammalian cells. We apply neutron spin echo,...

Description complète

Détails bibliographiques

Auteurs principaux:	Thomas-O Peulen, Carola S Hengstenberg, Ralf Biehl, Mykola Dimura, Charlotte Lorenz, Alessandro Valeri, Julian Folz, Christian A Hanke, Semra Ince, Tobias Vöpel, Bela Farago, Holger Gohlke, Johann P Klare, Andreas M Stadler, Claus AM Seidel, Christian Herrmann
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2023-06-01
Collection:	eLife
Sujets:	single-molecule fluorescence spectroscopy electron paramagnetic resonance small-angle x-ray scattering neutron spin-echo spectroscopy computer simulations large gtpases
Accès en ligne:	https://elifesciences.org/articles/79565
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!