PLPP/CIN Regulates Seizure Activity by the Differential Modulation of Calsenilin Binding to GluN1 and Kv4.2 in Mice

Calsenilin (CSEN) binds to Kv4.2 (an A-type K+ channel) as well as N-methyl-D-aspartate receptor (NMDAR), and modulates their activities. However, the regulatory mechanisms for CSEN-binding to Kv4.2 or NMDAR remain elusive. Here, we demonstrate the novel role of pyridoxal-5′-phosphate phosphatase/ch...

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Hlavní autoři:	Ji-Eun Kim, Hye-Won Hyun, Su-Ji Min, Duk-Shin Lee, A Ran Jeon, Min Ju Kim, Tae-Cheon Kang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2017-09-01
Edice:	Frontiers in Molecular Neuroscience
Témata:	cofilin dendritic spine DREAM epilepsy F-actin KChIP3
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00303/full
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