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NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

The DUX4 transcription factor is encoded by a retrogene embedded in each unit of the D4Z4 macrosatellite repeat. DUX4 is normally expressed in the cleavage-stage embryo, whereas chromatin repression prevents DUX4 expression in most somatic tissues. Failure of this repression causes facioscapulohumer...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Amy E Campbell, Sean C Shadle, Sujatha Jagannathan, Jong-Won Lim, Rebecca Resnick, Rabi Tawil, Silvère M van der Maarel, Stephen J Tapscott
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2018-03-01
Rangatū:eLife
Ngā marau:
DUX4
D4Z4
NuRD
CAF-1
facioscapulohumeral dystrophy
MBD3L
Urunga tuihono:https://elifesciences.org/articles/31023
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