YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease

Alzheimer's disease (AD) is the major form of dementia in the elderly and is closely related to the toxic effects of microglia sustained activation. In AD, sustained microglial activation triggers impaired synaptic pruning, neuroinflammation, neurotoxicity, and cognitive deficits. Accumulating evide...

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Autori principali:	Jinfeng Sun, Fan Chen, Lingyu She, Yuqing Zeng, Hao Tang, Bozhi Ye, Wenhua Zheng, Li Xiong, Liwei Li, Luyao Li, Qin Yu, Linjie Chen, Wei Wang, Guang Liang, Xia Zhao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-01-01
Serie:	Acta Pharmaceutica Sinica B
Soggetti:	Alzheimer's disease YOD1 Myosin heavy chain 9 Microglia Inflammation Cognitive dysfunction
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211383524004532
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