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The persistent inhibitory properties of saxagliptin on renal dipeptidyl peptidase-4: Studies with HK-2 cells in vitro and normal rats in vivo

Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic study using normal rats. In HK-2 cells, the inhibit...

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Principais autores: Masako Uchii, Mariko Sakai, Yuhei Hotta, Satoshi Saeki, Naoya Kimoto, Akinori Hamaguchi, Tetsuya Kitayama, Shunji Kunori
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-11-01
Serier:Journal of Pharmacological Sciences
Fag:
Dipeptidyl peptidase-4 inhibitor
Saxagliptin
Sitagliptin
Renal dipeptidyl peptidase-4
Renal tubular cells
Online adgang:http://www.sciencedirect.com/science/article/pii/S134786131730172X
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