The persistent inhibitory properties of saxagliptin on renal dipeptidyl peptidase-4: Studies with HK-2 cells in vitro and normal rats in vivo

Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic study using normal rats. In HK-2 cells, the inhibit...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Masako Uchii, Mariko Sakai, Yuhei Hotta, Satoshi Saeki, Naoya Kimoto, Akinori Hamaguchi, Tetsuya Kitayama, Shunji Kunori
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2017-11-01
Rangatū:	Journal of Pharmacological Sciences
Ngā marau:	Dipeptidyl peptidase-4 inhibitor Saxagliptin Sitagliptin Renal dipeptidyl peptidase-4 Renal tubular cells
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S134786131730172X
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!