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The latency-associated transcript locus of herpes simplex virus 1 is a virulence determinant in human skin.

Herpes simplex virus 1 (HSV-1) infects skin and mucosal epithelial cells and then travels along axons to establish latency in the neurones of sensory ganglia. Although viral gene expression is restricted during latency, the latency-associated transcript (LAT) locus encodes many RNAs, including a 2 k...

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Autors principals: Emilia A H Vanni, Joseph W Foley, Andrew J Davison, Marvin Sommer, Dongmei Liu, Phillip Sung, Jennifer Moffat, Leigh Zerboni, Ann M Arvin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2020-12-01
Col·lecció:PLoS Pathogens
Accés en línia:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009166&type=printable
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