OXA-23 β-Lactamase Overexpression in Acinetobacter baumannii Drives Physiological Changes Resulting in New Genetic Vulnerabilities

ABSTRACT β-Lactamase expression is the major mechanism of resistance to penicillins, cephalosporins, and carbapenems in the multidrug-resistant (MDR) bacterium Acinetobacter baumannii. In fact, stable high-level expression of at least one β-lactamase has been rapidly increasing and reported to occur...

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Hauptverfasser:	Jennifer M. Colquhoun, Marjan Farokhyfar, Anna R. Hutcheson, Alexander Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2021-12-01
Schriftenreihe:	mBio
Schlagworte:	Acinetobacter beta-lactamases peptidoglycan
Online-Zugang:	https://journals.asm.org/doi/10.1128/mBio.03137-21
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