Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

Although the classical biological protein cell cycle protein kinase CDK2 has been extensively studied in higher vertebrates, its function in lower vertebrates beyond the regulation of mitosis remains unknown. In this study, we report a distinct mechanism whereby IFN expression is negatively regulate...

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Detalles Bibliográficos

Principais autores:	Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Bao-Jie Cui, Yang-Yang Wang, Ke-Jia Han, Xiao Xu, Chu-Jing Zhou, Xiao-Yu Zhou, Yue Wu, Na Xu, Xiao-Li Yang, Dan-Dan Chen, Xiyin Li, Li Zhou, Shun Li
Formato:	Artigo
Idioma:	Inglês
Publicado:	eLife Sciences Publications Ltd 2026-01-01
Series:	eLife
Assuntos:	CDK2 TBK1 ubiquitination Dtx4 IFN
Acceso en liña:	https://elifesciences.org/articles/98357
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