A Method for Using Cell-Penetrating Peptides for Loading Plasmid DNA into Secreted Extracellular Vesicles

The low bioavailability and high toxicity of plasmid DNA (pDNA)-based therapeutics pose challenges for their in vivo application. Extracellular vesicles (EVs) have great potential to overcome these limitations, as they are biocompatible native cargo carriers. Various methods for loading pDNA into EV...

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Hlavní autoři:	Jekaterina Nebogatova, Heleri Heike Härk, Anett Puskar, Ly Porosk, Paolo Guazzi, Moataz Dowaidar, Ülo Langel, Kaido Kurrikoff
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-12-01
Edice:	Biomolecules
Témata:	extracellular vesicles gene therapy nucleic acid therapeutics drug delivery system cell-penetrating peptides
On-line přístup:	https://www.mdpi.com/2218-273X/13/12/1751
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