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A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells

Abstract Background Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, which is associated with poor prognosis. Herceptin and other agents targeting HER2 have potent antitumor efficacy in patients with HER2-positive cancers. However, the development of drug resista...

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Библиографические подробности
Главные авторы: Shengnan Yu, Jing Zhang, Yongxiang Yan, Xudong Yao, Lijuan Fang, Hui Xiong, Yang Liu, Qian Chu, Pengfei Zhou, Kongming Wu
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2019-08-01
Серии:Journal of Experimental & Clinical Cancer Research
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Online-ссылка:http://link.springer.com/article/10.1186/s13046-019-1354-1
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