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Targeting the PBX1–BCL2L1 axis as a therapeutic strategy in colorectal cancer

Abstract Pre-B-cell leukemia homeobox 1 (PBX1) is a transcription factor involved in diverse cellular processes, but its role in colorectal cancer (CRC) remains incompletely understood. In this study, we show that PBX1 is downregulated in CRC tissues and cell lines. Functional experiments revealed t...

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Principais autores: Hao Lin, Ting Su, Ying Liu, Ruilan Deng, Jie Li, Xuanhao Lin, Qiaoling Ke, Yijing Luo, Lele Meng, Bin Liang, Xuhong Song, Dongyang Huang, Lingzhu Xie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2026-05-01
coleção:Cell Death Discovery
Acesso em linha:https://doi.org/10.1038/s41420-026-03139-2
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