Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in <i>Staphylococcus epidermidis</i>

Herein, 15 phenylpiperazine 3-benzyl-5,5-dimethylhydantoin derivatives (<b>1</b>–<b>15</b>) were screened for modulatory activity towards Msr(A) efflux pump present in <i>S. epidermidis</i> bacteria. Synthesis, crystallographic analysis, biological studies in vitro and structure–activity relationshi...

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Detalhes bibliográficos

Principais autores:	Karolina Witek, Gniewomir Latacz, Aneta Kaczor, Joanna Czekajewska, Ewa Żesławska, Anna Chudzik, Elżbieta Karczewska, Wojciech Nitek, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-08-01
Colecção:	Molecules
Assuntos:	<i>Staphylococcus epidermidis</i> efflux pump Msr(A) phenylpiperazine 5,5-dimethylhydantoins efflux pump inhibitors EPIs
Acesso em linha:	https://www.mdpi.com/1420-3049/25/17/3788
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