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Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not completely understood as intermediate states remain poorly characterized by structural approaches. In a previous study on the prototypic bacterial proton-gated cha...

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Библиографические подробности
Главные авторы: Solène N Lefebvre, Antoine Taly, Anaïs Menny, Karima Medjebeur, Pierre-Jean Corringer
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications Ltd 2021-09-01
Серии:eLife
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Online-ссылка:https://elifesciences.org/articles/60682
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