Zinc overload disrupts SoxR [2Fe–2S] clusters to drive redox-metallic crosstalk via SoxS-ZnuACB in Escherichia coli

Here, we demonstrate that excess zinc disrupts bacterial redox sensing by specifically disassembling the [2Fe–2S] cluster of SoxR – a master oxidative stress sensor in Escherichia coli. This impairment couples zinc overload to dysregulated oxidative defense, revealing a previously unrecognized metal...

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Hlavní autoři:	Jie Feng, Feng Liang, Yongguang Zhou, Shihao Wen, Yue Chen, Binjie Ge, Wenjing Zhang, Jie Wang, Runyu Chen, Yin Zhang, Jianghui Li, Wu Wang, Guoqiang Tan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-03-01
Edice:	Redox Biology
Témata:	Iron sulfur cluster Oxidative stress Zinc homeostasis SoxR Redox regulation Redox cycling reagent
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S221323172600011X
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