Zinc overload disrupts SoxR [2Fe–2S] clusters to drive redox-metallic crosstalk via SoxS-ZnuACB in Escherichia coli
Here, we demonstrate that excess zinc disrupts bacterial redox sensing by specifically disassembling the [2Fe–2S] cluster of SoxR – a master oxidative stress sensor in Escherichia coli. This impairment couples zinc overload to dysregulated oxidative defense, revealing a previously unrecognized metal...
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| Główni autorzy: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Elsevier
2026-03-01
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| Seria: | Redox Biology |
| Hasła przedmiotowe: | |
| Dostęp online: | http://www.sciencedirect.com/science/article/pii/S221323172600011X |
| Etykiety: |
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