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Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

Abstract mTOR (mechanistic target of rapamycin) kinase is a pivotal regulator of cellular growth and metabolism, integrating signals from nutrients and growth factors. It functions through the assembly of two distinct complexes, mTORC1 and mTORC2, which differ in their substrate specificity and regu...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Keshav Gupta, Nagalakshmi Kommineni, Tanuja Bogadi, Neeraja P Alamuru-Yellapragada, Subbareddy Maddika
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Nature 2025-09-01
Saila:EMBO Reports
Gaiak:
Sarrera elektronikoa:https://doi.org/10.1038/s44319-025-00576-5
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