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Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues

The use of patient-derived organoids (PDO) as a valuable alternative to in vivo models significantly increased over the last years in cancer research. The ability of PDOs to genetically resemble tumor heterogeneity makes them a powerful tool for personalized drug screening. Despite the extensive opt...

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Principais autores: Mattia Marinucci, Caner Ercan, Stephanie Taha-Mehlitz, Lana Fourie, Federica Panebianco, Gaia Bianco, John Gallon, Sebastian Staubli, Savas D. Soysal, Andreas Zettl, Stephan Rauthe, Jürg Vosbeck, Raoul A. Droeser, Martin Bolli, Ralph Peterli, Markus von Flüe, Charlotte K. Y. Ng, Otto Kollmar, Mairene Coto-Llerena, Salvatore Piscuoglio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-01-01
coleção:Frontiers in Oncology
Assuntos:
patient-derived organoids
colorectal cancer
Primocin
antibiotics
microbial contamination control
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2021.781833/full
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