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An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed mathematical modelling of gene regulatory networks i...

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Principais autores: James Davies, Andres F. Vallejo, Sofia Sirvent, Gemma Porter, Kalum Clayton, Yamkela Qumbelo, Patrick Stumpf, Jonathan West, Clive M. Gray, Nyaradzo T. L. Chigorimbo-Murefu, Ben MacArthur, Marta E. Polak
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-06-01
Serier:Frontiers in Immunology
Fag:
Langerhans cells
single cell transcriptomics
gene regulatory network
mathematical modelling
adaptive immunity
immunotolerance
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.665312/full
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