An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed mathematical modelling of gene regulatory networks i...

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Autors principals:	James Davies, Andres F. Vallejo, Sofia Sirvent, Gemma Porter, Kalum Clayton, Yamkela Qumbelo, Patrick Stumpf, Jonathan West, Clive M. Gray, Nyaradzo T. L. Chigorimbo-Murefu, Ben MacArthur, Marta E. Polak
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-06-01
Col·lecció:	Frontiers in Immunology
Matèries:	Langerhans cells single cell transcriptomics gene regulatory network mathematical modelling adaptive immunity immunotolerance
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.665312/full
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