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Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics

BackgroundLactate-driven metabolic reprogramming and histone lactylation play pivotal roles in bladder cancer (BLCA) progression, yet their underlying mechanisms and regulatory genes remain poorly understood.MethodsUsing transcriptomic data from The Cancer Genome Atlas (TCGA), we identified lactylat...

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Bibliografiske detaljer
Principais autores: Yanjun Chen, Yu Sun, Xiaoyan Liu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-07-01
Serier:Frontiers in Immunology
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604758/full
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